MACKAY & MATTHEWS LAB

Protein structure, function and engineering

The latest update in our travails with the NuRD complex!

Feb 19, 2020

We have posted our analysis of NuRD complex architecture on Biorxiv. We firm up the stoichiometry, show that there is large-scale dynamics, partially map architecture using XLMS and show direct competition by PWWP2A that steals half the complex! It’s been a massive effort over many years by many lab members and collaborators (most significantly Michael Landsberg at UQ) – with Jason Low and Ana Silva leading the way. Check it out here while we try to find a publication home for it…

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