After about 7 years of painstaking work (!), we have finally been able to solve and publish the structure of the complex formed between the N-terminal zinc finger of GATA-1 and a classical finger from FOG. This work was made very difficult by the weak nature of the complex (~104-105 M-1), which presented line-broadening problems.
Finally though, we got there and were able to report the structure in PNAS (Track II) – a great relief for all involved! Now to bring in other members of these complexes…
Auf wiedersehen Jakob…
Auf wiedersehen Jakob…
Jakob Helmbrecht bravely ventured down under, risking crocodile attacks and leech bites to work...