The long-awaited structure of the double ZF of GATA1 bound to DNA – a pseudopalindromic site – has come out [Pubmed or PDF via journal] in Protein Science, thanks to the work of Lorna (including some *very* funky multi-coloured gel shifts), Krystal and Nina – and of course the inimitable David Jacques and Mitchell. Their work puts a dampener on the idea that GATA-1 might mediate DNA looping by having one ZF bind to a local site and the other to a distant site – which is just as well, otherwise Ldb1 would be left feeling redundant.
It’s good to see that when I go away, the lab is still productive!
It’s good to see that when I go away, the lab is still productive!
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