The long-awaited structure of the double ZF of GATA1 bound to DNA – a pseudopalindromic site – has come out [Pubmed or PDF via journal] in Protein Science, thanks to the work of Lorna (including some *very* funky multi-coloured gel shifts), Krystal and Nina – and of course the inimitable David Jacques and Mitchell. Their work puts a dampener on the idea that GATA-1 might mediate DNA looping by having one ZF bind to a local site and the other to a distant site – which is just as well, otherwise Ldb1 would be left feeling redundant.
Honours ice cream celebration!
Honours ice cream celebration!
The BSc Hons students for 2024 have given all the talks, submitted all the theses and generally...