Ana’s paper describing the structure of a slightly cryptic domain from CHD4 has come out in JBC. Check out the paper here or check out the structure here. As you can see here, it looks sort of like an HMG-box domain (CHD4 is in red – HMG-box domains are in grey). HMG-box domains bind to DNA – sometimes to unusual structures… Seems like it might be involved in binding to PAR at sites of DNA damage, although that’s not set in stone at this stage…