[ PDB file ] [ PubMed link ]
The (�a)8 barrel is one of the most common protein folds and it is thought it was one of the very first protein folds to emerge. Our collaborator Wayne Patrick previously isolated a three-quarter barrel that is soluble and almost as thermostable as full-length protein (PRAI). Our NMR structure of this three-quarter barrel shows that, despite missing a quarter of the normal foled, the subdomain is monomeric, well ordered and adopts a native-like structure in solution. These proteins – they’re crazy…