[ PDB file ] [ PubMed link ]
Ana identified and determined the structure (using NMR – rather than her favoured crystallographic method…) of a small domain from the N-terminal region of the chromatin remodeller CHD4 (a member of our favourite chromatin remodelling complex). The domain resembles HMG-type domains that are often involved in non-specific DNA binding. Binding experiments suggest that this domain might have a penchant for poly-ADPribose – a branched chain nucleic acid that is found at sites of DNA damage (where NuRD is also found…).