[ PDB file ] [ PubMed link ]
All GATA1-activated genes are co-occupied by LMO2, LDB1 and a number of other proteins. As part of a project to understand how these proteins come together at such gene promoters, we have determined the solution structure of the C-terminal LIM domain of LMO2 bound to its cognate target peptide in ldb1. This domain is able to bind to the N-terminal zinc finger of GATA1 – and we have used NMR data to build a model of this complex (see above!).