[ PDB file ] [ PubMed link ]
All GATA1-activated genes are co-occupied by LMO2, LDB1 and a number of other proteins. Here, we have used a range of NMR and mutagenesis data to create a model of the complex formed by LMO2, LDB1 and the GATA1 N-finger. Surprisingly, the model suggests that GATA1 N-finger will also be able to contact FOG1 at the same time as LMO2 and gives us more insight into the molecular details surrounding gene activation by multi-protein transcriptional assemblies.