MACKAY & MATTHEWS LAB

Protein structure, function and engineering

Beautiful, but CruEL…

Dec 8, 2020

Well, it’s one of those classic structural biology stories… Scientist (Anjumara) purifies and crystallizes protein, gets 3-A dataset at synchrotron (with Chandrika’s help). Can’t be solved, but scientists ask cryoEM colleagues kindly and they acquire some images (thanks Alastair and James!). Images are exquisite and quickly yield a 3-4 A map…..of GroEL. Scientists then have a good model for molecular replacement, and – lo and behold – can now solve crystal structure…. of GroEL…

Hard not to admire the beauty of the structure though!

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Joels NBD…

Joels NBD…

...which means New Bike Day in bike geek lingo... Joel has spent a bit of time (well, quite a...

Priya + 1

Priya + 1

Priya Thaivalappil - who worked with Joel as a Research Assistant way back in 2014 - is now the...