The first step in the publication journey… This is the paper that describes our BET inhibitors that are super-selective – one of which seems to act by sensing differences in conformational dynamics between paralogues. It only binds to BRD2-BD1 – the only BD1 that shows *no* ms-us timescale dynamics. Very cool (we think)! We’ve sent it to a journal – let’s hope we don’t have to send it to 20!
You can find it here, in all its glory: http://biorxiv.org/content/early/2025/09/24/2025.09.24.678353
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