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Janet’s structure of the LMO2:ldb1 complex published in EMBO J.
The structure of the complex formed between full-length LMO4 and the LMO4-binding region of ldb1 was published recently in EMBO J. This structure revealed a very unusual binding mode - a tandem beta-zipper, in which the ldb1 forms additional beta-strands to add on to hairpins in both of the LIM domains. The structure provides an extremely extended interface, and Daniel and others have been able to map the important residues for binding using mutagenesis and yeast two-hybrid experiments. Now the design work can begin!
Janet wins Young Brilliance prize
Janet Deane was awarded the Young Brilliance prize from the Cure Cancer Australia Foundation last night. This prize is awarded annually to an Australian PhD student who has made an outstanding contribution to understanding and curing cancer. The award was presented at a gala dinner at UNSW, and Janet has been receiving lots of attention from the press!
Dave wins Applied Biosystems Edman Award
Dave Gell won the Edman Award from the ASBMB - a prize given to postdoctoral researchers with less than seven years experience after completing their PhD. Dave will present his work at ComBio 2004 (in Perth) and receive a big dollop of cash as well!
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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