MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Lab alum Kaavya smashing it in GPCR world

This week's edition of Science magazine features an article on which Kaavya Krishna Kumar - PhD student with Dave Gell when he was here in our unit - is first-equal author. The paper describes the cryoEM structure of the glucagon receptor bound to a glucagon-like ligand and helps understand the mechanism by which the binding of glucagon to its GPCR receptor transmits a signal to the inside of the cell - increasing glucose production when blood glucose gets low. Great work Kaavya! [Figure taken from paper - which you can find HERE]

Angela wins the oldest shaking incubator competition!

Our lab manager, Angela Nikolic, learned of a competition hosted by In Vitro Technologies on "who has the oldest shaking incubator" in all of Australia and New Zealand. She applied with our Infors Unitron Shaker that dated back to Dec 2000! She has won us a brand new Infors Celltron Shaker! Well done Angela!

Jessica hands in

Always a big milestone in the PhD journey, Jessica Zhong has clicked the upload button (which isn't quite the same as the old days with the endless photocopying and page juggling, but still...) and submitted her thesis (and now is an expert on definite articles), which was focused on the biochemical analysis of CHD4 - the chromatin remodelling component of the NuRD complex. Her project landed her a Nature Commun paper so far, and with the experiments she's about to finish off, hopefully another good paper too. And it would be remiss of me to not mention that the project has been a fantastic collaboration with Antoine van Oijen and Bishnu Paudel at University of Wollongong - big...

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Fionna publishes a nice paper!

Fionna publishes a nice paper!

Fionna has just had her first paper published from her postdoc with Fred Allain at the ETH in Zurich - in NSMB, no less! While simultaneously juggling a small child (not literally) she has published her structure of the zinc knuckle domains of Lin28 (an inhibitor...

More lab grant success

More lab grant success

In the recently announced ARC Discovery grant round, Joel was lucky enough to get his two applications funded (outcomes here) - one on zinc finger design and one on trying to figure out the function of our favourite RNA-binding protein A bit of a...

Richard Grant in the news

Richard Grant in the news

Richard Grant - ex-Mackay-lab postdoc, is now an associate editor at the Faculty of 1000 - the group of experts that review papers across a range of different fields and make note of ones that seem worth a read - and has been in the news recently with F1000's...

Jacqui gets elected…

Jacqui gets elected…

...to the Executive Council of the Protein Society. It is possible that she is the first person from down under to be elected to the Council! Expect a push for lab members to attend the Protein Society meetings! Actually, I went to one in Zurich not long ago and it...