MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Jason heads to Blighty

Former lab member Jason Schmidberger (postdoc 2015-6) has packed up his Akubra (and his family) and made a big move to the UK to join the drug discovery alliance and consulting company Evotec. Looks like an exciting company and we look forward to hearing from him what it's like out in the real world!

Big news (x2) for Michael Webster in Strasbourg

Michael - an Hons student in the lab in 2012 - has been extra productive in his postdoc in Strasbourg lately. Not only has he just had a paper come out in Science this week showing the interaction between bacterial RNA polymerase and the ribosome (the basis for the coupling of transcription and translation): [check it out here] but he has just become a father to Hugo! Busy boy! - and congratulations on both fronts...

Lab alum Kaavya smashing it in GPCR world

This week's edition of Science magazine features an article on which Kaavya Krishna Kumar - PhD student with Dave Gell when he was here in our unit - is first-equal author. The paper describes the cryoEM structure of the glucagon receptor bound to a glucagon-like ligand and helps understand the mechanism by which the binding of glucagon to its GPCR receptor transmits a signal to the inside of the cell - increasing glucose production when blood glucose gets low. Great work Kaavya! [Figure taken from paper - which you can find HERE]

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Fionna publishes a nice paper!

Fionna publishes a nice paper!

Fionna has just had her first paper published from her postdoc with Fred Allain at the ETH in Zurich - in NSMB, no less! While simultaneously juggling a small child (not literally) she has published her structure of the zinc knuckle domains of Lin28 (an inhibitor...

More lab grant success

More lab grant success

In the recently announced ARC Discovery grant round, Joel was lucky enough to get his two applications funded (outcomes here) - one on zinc finger design and one on trying to figure out the function of our favourite RNA-binding protein A bit of a...