MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Maryam submits!

Maryam looks slightly dazed for good reason - she has just handed in her PhD thesis - well inside the time allowed. Along the way, she decided that moving country to do a PhD wasn't sufficiently challenging and so upped the stakes by becoming a mother for the first time. That *still* seems to have been too easy, so I'm interested to see what the next challenge is that she sets herself! Congratulations Maryam - amazing effort - I am seriously impressed...

The latest update in our travails with the NuRD complex!

We have posted our analysis of NuRD complex architecture on Biorxiv. We firm up the stoichiometry, show that there is large-scale dynamics, partially map architecture using XLMS and show direct competition by PWWP2A that steals half the complex! It's been a massive effort over many years by many lab members and collaborators (most significantly Michael Landsberg at UQ) - with Jason Low and Ana Silva leading the way. Check it out here while we try to find a publication home for it...

Charlotte wins prize!

Charlotte Franck - who has been doing her PhD riding the line between Richard Payne's lab in Chemistry and Joel's lab - has had some payoff for the great work she's done on her evasin project, winning a poster prize at the 2020 Lorne Conference on Protein Structure and Function. [...and it could have been either partially due to or alternatively despite the suggestions Joel gave her...we'll never know!] Pictured here with emotional supporters Xavier and Hakimeh!

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Now *this* is an insect!

Now *this* is an insect!

You thought that it was the snakes, scorpions, sharks and spiders that you had to worry about in Australia. No one warned you about the monster stick insects though... check this out. You could put a leash on it and take it for a walk! The body was 20 cm...

Visiting academic in the lab

Visiting academic in the lab

A/Prof. Siavoush Dastmalchi is visiting the lab for 6 months from Tabriz University of Medical Sciences in Iran. Siavoush did his PhD at the University of Sydney with Bret Church (and also did some NMR work with us during that period). He has come to brush up on...

Fionna wins a fellowship

Fionna wins a fellowship

Fionna Loughlin, who finished her PhD with Joel in 2007, has just been awarded an ETH Postdoctoral Fellowship to work on the structural biology of protein-RNA complexes in the laboratory of Fred Allain in Zürich. Well done Fionna - thoroughly deserved!