MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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The Rock

In news of great excitement, I can announce that there is another lab matrimonial union on its way! Taylor and Rezwan have announced their engagement - in fine style while on a small weekend getaway in Mudgee. They have decided to make the most of the whole thing by having *3* weddings - so stay tuned to find out more! Congratulations to both of them!

Dave Gell’s new paper featuring old-school biochemistry

Molecular Microbiology has now published the epic piece of work spearheaded by ex-lab member Dave Gell, who is now resident at the University of Tasmania. Dave had been approached by local microbiologists who noted that some strains of Haemophilus haemolyticus inhibited the growth of Haemophilus influenzae. Dave heroically purified the factor that caused this inhibition by using culture medium - old school biochemistry! Amazingly, he found that it was a heme-binding protein - his favourite class of proteins! They could hardly have found a better person in the country to characterize this protein if they'd tried! Read all about it...

Our RaPID screening manuscript is up on bioRxiv

The project that Karishma has been hammering away at for the last couple of years - with substantial input from collaborators Louise Walport (Crick Institute, London) and Toby Passioura (now USyd) - has been somehow condensed into a manuscript and posted on bioRxiv HERE. It's a massive amount of work by them and by far the most comprehensive study of what sort of things come out of a RaPID screen (see crystal structures from the manuscript arrayed below...) - let's see if we can convince someone to publish...

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Joel wins 100-mile race!

Joel wins 100-mile race!

On the weekend, Joel ran in the Great North Walk 100-miler, run (oddly enough) on the Great North Walk between Newcastle and the northern reaches of Sydney (Patonga). Improbably, he crossed the line first in 26 h 31 min - his first ever win in a solo race. Soon he...

Fellowship success

Fellowship success

Not only will we be able to buy tips, but Joel and Jacqui will also be able to feed their cats next year. Both of us have secured NHMRC fellowships (SRF B level) to keep us off the streets for the next five years. What a relief!

Grant success

Grant success

Hooray - we will be able to buy pipette tips next year! Joel was awarded two ARC Discovery Grants and Jacqui one. Joel's two projects are focused on (a) new functions for zinc finger transcription factors (in collaboration with Merlin Crossley) and (b) novel...

Wendy on the radio

Wendy on the radio

Wendy Yung, an MSc graduate from the Mackay lab, appeared on ABC National Radio the other day. Wendy has been working at Questacon, the National Science and Technology Centre, for a number of years now, and travels around the country with their science roadshow,...

Mudgha is in the money…

Mudgha is in the money…

Mugdha Bhati, a smiley PhD student from Jacqui's lab, has been busy winning prizes and fellowships to attend a couple of crystallography conferences. She was awarded a Maslen scholarship from the Society of Crystallographers in Australia and New Zealand to go to...