MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Lab alumnus Michael Webster publishes his first last-author paper – in Cell!

Michael, a BSc Hons student in the lab in 2012, now has an independent group leader position at the highly regarded John Innes Center for Plant Science in the UK. He has just reported his structure of the RNA polymerase from plant plastids - in a paper in Cell - in the same issue as a rival group published a similar study! Our very own (well, until recently) Jason Low gave them a helping hand by collecting XLMS data on their complex, which helped them place subunits into the electron potential map that they obtained from single-particle cryoelectron microscopy data. Super start to one's independent career.

Lab walk in the Blue Mountains

We ventured out into the lower Blue Mountains for a day hike on Sat 24 Feb. The forecast was that there might be some rain. And there was. The first couple of hours were persistent - though not heavy - rain. Fortunately the canopy protected us from some direct rainfall, but all of the surrounding shrubbery was saturated, and so we all were too. Still, it was warm enough that it didn't feel too miserable! The leeches were pretty happy about the weather though - and they were very keen to join us on our walk. In the end, I think Lucien might have won the prize for the most leech-friendly hiker, with about 20 bites - not that it was a competition. First, we headed down from Springwood on...

The lab hits the big time on Youtube

We recently had a camera crew in the lab from Horticultural Innovation Australia. They are providing some funding for our work to design new, selective pesticides targeting the Varroa mite that has made its way to Australian in the last year or so and is causing much concern (it's already been causing much concern in the rest of the world for some years!). They spent a long time taking footage and in the end we made the cut to their 2023 annual report video...which you can see here. Today, the Hort Innovation annual report, tomorrow Hollywood...!

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Oscar’s Hut2Hut 2022

Oscar’s Hut2Hut 2022

Oscars Hut2Hut is a 100-km trail run in the Victorian Alps with epic amounts of ascent and descent (5800 m of each) and a *lot* of technical sections. A good chunk of it is above the treeline with spectacular 360-degree views - on a good day... which is the...

It’s raining babies!

It’s raining babies!

Recent PhD graduate Mehdi and his wife Diba have just welcomed a new family member - their daughter Rosha who was borne at 00:34 on 9 August this year. All are healthy and raring to go on their latest project. And you thought the NuRD complex was challenging,...

Welcome to Adnan Shaik!

Welcome to Adnan Shaik!

Dr Anjumara Shaik, who has been working with our collaborator Alyson Ashe on transgenerational epigenetic inheritance, has just become a new mother on 3 June - and here you can see her husband Asif Pasha and her new son Adnan (who doesn't look that pleased about...