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Karishma (and Biswa’s) magnum opus makes it onto Biorxiv
The first step in the publication journey... This is the paper that describes our BET inhibitors that are super-selective - one of which seems to act by sensing differences in conformational dynamics between paralogues. It only binds to BRD2-BD1 - the only BD1 that shows *no* ms-us timescale dynamics. Very cool (we think)! We've sent it to a journal - let's hope we don't have to send it to 20! You can find it here, in all its glory: http://biorxiv.org/content/early/2025/09/24/2025.09.24.678353
Dorothy ties the knot!
Former Mackay lab PhD student Dorothy Wai - author of such well-known studies as "The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators" has recently tied the knot with her beau Ben down in Melbourne. All reports indicate that she didn't set anything on fire during the ceremony, and that she is currently scheming to find the best way to introduce plants and cats into their household - looks like the plants will be a cakewalk but that the cats will require a strategy of greater cunning. Congratulations Dorothy (and Ben)! [envira-gallery...
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
Joel and Taylor go *big* at Strathfield North Public School
Joel has been doing outreach at Strathfield North Public School for about a dozen years now - working the whole time with teacher Filomena Catanzariti. For all of those years, I've desparately wanted to run over a swimming pool filled with oobleck, to demonstrate...
Jessica, Karishma and Charlotte band together to win Seed Funding Grant
Dr Jessica Zhong has recruited two other ECR colleagues - Dr Karishma Patel and Dr Charlotte Franck - to win a $50,000 reserach grant to support work aimed at developing peptide nucleic acids (PNAs) as possible solutions to the antibiotic resistance crisis. Totally...
Varroa pesticide work hits the headlines
Unsurprisingly, there has been a significant surge in interest in Varroa mites in the last month or so, with the outbreak in NSW. This has resulted in quite a lot of publicity for our work on selective pesticides to tackle the mite, with the latest being an article...
Varroa research gets a mention in Japan!
Japan's Science and Technology Agency has picked up the recent publicity around our Varroa-mite-specific pesticide project by featuring it briefly on their website. Tash will be able to read it to...
A NuRD for all seasons…
...is the title of our new review that is going to appear in Trends in Biochem Sci very soon. A sneak preview is here. In the paper - shaped by Xavier and Jason - we ponder on the observation that multiple paralogues are observed for all members of our favourite...
Varroa work in the spotlight
Our work to design safer insecticides - particularly ones targeting honeybee pests (which was funded recently by Horticultural Innovations Australia) - has become more immediately topical overnight with a report (and followups 1 2) that the dreaded Varroa mite has...
Rogaine outing with collaborator Alyson Ashe
Joel and Alyson participated in the 2022 Paddy Pallin 6-hour rogaine yesterday - organized by the NSW Rogaining Association. Weather was perfect and had a fantastic outing - Alyson's first ever rogaine, but she smashed it - a complete natural. Running strongly the...
New lab preprint – on the mechanism of CHD4-driven chromatin remodelling
Our new preprint has taken forever but is now on biorxiv - WHEW! We (Jessica, Hakimeh, and Bishnu - with great support from Jason, Ana, Stefan, Chandrika - and Santosh at the Synchrotron) examine the auxiliary domains of chromatin remodeller CHD4, finding an IDR...
New manuscript on Biorxiv
Sandra Hake, our collaborator with a strong interest in histone variants and chromatin in general, has uploaded her latest manuscript to Biorxiv - a paper that focuses on the function of the chromatin associated protein HMG20A. Hakimeh has put her protein...
April graduation!
Last week, we had one of the first live graduations we'd had for some time, and it was a bumper one - Angus, Marcus and Jen all graduated with their undergraduate degrees, as did Lou Irish from Ann's lab. So, it was all over to the old quad to congratulate them and...
Ingrid becomes a mother….again!
Ingrid was as organized as usual, and gave birth to baby Scarlett at 7:20 am on April 9. Current reports are that Scarlett has not learned yet to cry, but communicates in a series of small toy-like squeaks - they can only hope that continues for some time......
New research funding to develop selective insecticides!
Joel and Ron, teamed up with fellow SOLES academic Dr Emily Remnant, have been successful in procuring funding from Horticultural Innovation Australia (HIA) to create new insecticides that are safer and more selective. HIA collect levies from a wide range of...