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Mehdi and Jason’s paper accepted at FEBS J
In exciting news, we have had our paper "The stoichiometry and interactome of the Nucleosome Remodelling and Deacetylase (NuRD) complex are conserved across multiple cell lines" accepted in FEBS J [epub here]. It's particularly exciting both because it's Mehdi's first first-author paper from his PhD and it is also Jason's first last- and corresponding-author paper. Congratulate them if you see them... The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex is conserved across multiple cell...
Ingrid’s life changes dramatically…
Congratulations to Ingrid and Percy on the successful and drama-free (as much as it can be) birth of their son Toby Macindoe. He was born on Feb 18 at Prince of Wales and both he and his mother are doing just fine!
A nice piece of work from Nina
Nina Ripin, who spent some months in the lab as a Masters' student in 2011, is the lead author on a nice study focused on the RNA-binding properties of HuR in the latest PNAS. She has combined NMR and X-ray crystallography while working in Fred Allain's lab at ETH in Zurich to characterize the means by which this protein uses its RRM domains to bind to AU-rich RNA elements. You can read it here.
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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