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What more could you ask for…
...as a thank you PhD present? I can't decide which is my favourite part - the craft beer, the Clif bars that have been lovingly brought all the way from the US or the NMR needlepoint! Well, OK, I can decide... Thanks very much Taylor! And great to hear that the STEM job at UTS is going like a train!
Fionna’s new protein-RNA complex structure appears in Molecular Cell
Lab alumna Fionna Loughlin - now working at Monash - has published the culmination of several years of her postdoctoral work in Fred Allain's lab at ETH in Zurich just last week in Molecular Cell [here]. She has determined the structures of several domains of the protein FUS bound to RNA sequences, and shown how they contribute to FUS-mediated splicing. FUS biology/biochemistry is a hot topic these days - given it's ability to form phase-separated structures - so it's good timing. Top effort pushing this through, Fionna!
Taylor hands in…
...and stops herself from otherwise going mad! Hooray - well done Taylor! Now you can get back to all those things you used to do, like sleeping, not spending every weekend in front of a computer in the lab - that sort of thing...
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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