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Paper featured in special edition of JBC!
JBC is putting out a special virtual issue with a focus on protein science in Australasia to honour the Lorne Protein conference and we received word that one of our papers is featured! "CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex" is a collaborative effort with Nick Shepherd involving Jason, Ana, and Sarah Webb. Big congratulations all around! Issue found here: http://www.jbc.org/site/vi/
Lab Retreat 2017- Hyam’s Beach
The lab headed down to Hyam's for the weekend for our annual retreat! Games were played, a delicious group dinner was had, sights were taken in, and many kangaroos were spotted (sadly after Mehdi and Diba left).
Super-duper HSQC titration data
Karishma has been busily recording HSQC spectra for a whole set of protein-peptide interactions we're looking at (let's see - there are 18 peptides and 6 proteins - so she has about 108 titrations to do if we go the whole hog). So far, a decent proportion of them have been exceptionally good - like these! An embarrassment of riches...
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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