MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Dorothy’s paper accepted at NAR

Dorothy has had a pretty painless first foray into the world of publishing papers with her paper on the RNA-binding properties of the transcription factor YY1 being accepted at Nucleic Acids Research. We were very pleased with the outcome given that we weren't trumpeting sequence-specific binding with high affinity, but rather low specificity and moderate affinity binding... Congratulate her if you see her!

Lab Hyams beach trip all done

The annual pilgrimage to Hyams Beach has been and gone - perfect weather and we didn't even get told off for being too noisy! Photos here.

Our latest CHD4 work makes it into JBC

Well, this one wasn't *quite* as straightforward as the Protein Science paper I mentioned recently, but in the end the reviewers *did* actually improve the paper I think. You can read about the efforts of Jason (L), Sarah, Ana, Hinnerk, Mario, Mattias and Nick - with able assistance from Daniel in Canberra and Ben Parker - when you discover that CHD4 is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex.

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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