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Our first EM data published in Protein Science
Whew! It was quite a roller coaster ride to this paper. After seeing an abstract by John Schwabe's group in Leicester that covered work very similar to what we've been hammering away at for a while, we scrambled to get a paper prepared and submitted. During the process, I contacted a number of journals and asked them what their policy was if a paper we had under review with them was scooped (in another journal) during the review process. There was a range of responses (interestingly, it's not specified on many journal websites), but Protein Science said they'd ignore anything that comes out during the review process, so we went with them. It was a great journal experience (and heaven...
Bye bye Chay! – and hello Ninnie
Today we said bon voyage (or perhaps veilige reis) to Chayenne - our Dutch intern who has been with us for the last year. I'm pretty sure she qualified as the youngest person we have had in the lab, and she became an integral part of the Mackay lab while she was here... Apparently we might have convinced her to go back and study structural biology now - so that was a job well done! Don't forget us down here Chay! Ninnie Wybrands has turned up just at the right time to fill that space in the lab though, so we're looking forward to having her with us for the next 5 months.
Ana’s CHD4 paper comes out
Ana's paper describing the structure of a slightly cryptic domain from CHD4 has come out in JBC. Check out the paper here or check out the structure here. As you can see here, it looks sort of like an HMG-box domain (CHD4 is in red - HMG-box domains are in grey). HMG-box domains bind to DNA - sometimes to unusual structures... Seems like it might be involved in binding to PAR at sites of DNA damage, although that's not set in stone at this...
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!
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