MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Ana’s CHD4 paper comes out

Ana's paper describing the structure of a slightly cryptic domain from CHD4 has come out in JBC. Check out the paper here or check out the structure here. As you can see here, it looks sort of like an HMG-box domain (CHD4 is in red - HMG-box domains are in grey). HMG-box domains bind to DNA - sometimes to unusual structures... Seems like it might be involved in binding to PAR at sites of DNA damage, although that's not set in stone at this...

Ivan hands in!!

In a momentous occasion - for both Jacqui and Ivan - Ivan has handed in his PhD thesis. It was a mission, but it is a mission that has been completed!

Roland lands a job!

Roland - postdoc in the lab from 2006 till 2011 - has landed himself a Level B academic position in the School of Science and Health at Western Sydney University. He and Liza will make a great wife-and-husband team as they continue to build their lab together out at WSU. Fantastic news Roland - definitely a champagne occasion!

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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