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Bye bye Chay! – and hello Ninnie
Today we said bon voyage (or perhaps veilige reis) to Chayenne - our Dutch intern who has been with us for the last year. I'm pretty sure she qualified as the youngest person we have had in the lab, and she became an integral part of the Mackay lab while she was here... Apparently we might have convinced her to go back and study structural biology now - so that was a job well done! Don't forget us down here Chay! Ninnie Wybrands has turned up just at the right time to fill that space in the lab though, so we're looking forward to having her with us for the next 5 months.
Ana’s CHD4 paper comes out
Ana's paper describing the structure of a slightly cryptic domain from CHD4 has come out in JBC. Check out the paper here or check out the structure here. As you can see here, it looks sort of like an HMG-box domain (CHD4 is in red - HMG-box domains are in grey). HMG-box domains bind to DNA - sometimes to unusual structures... Seems like it might be involved in binding to PAR at sites of DNA damage, although that's not set in stone at this...
Ivan hands in!!
In a momentous occasion - for both Jacqui and Ivan - Ivan has handed in his PhD thesis. It was a mission, but it is a mission that has been completed!
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