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Dorothy’s paper accepted at NAR
Dorothy has had a pretty painless first foray into the world of publishing papers with her paper on the RNA-binding properties of the transcription factor YY1 being accepted at Nucleic Acids Research. We were very pleased with the outcome given that we weren't trumpeting sequence-specific binding with high affinity, but rather low specificity and moderate affinity binding... Congratulate her if you see her!
Lab Hyams beach trip all done
The annual pilgrimage to Hyams Beach has been and gone - perfect weather and we didn't even get told off for being too noisy! Photos here.
Our latest CHD4 work makes it into JBC
Well, this one wasn't *quite* as straightforward as the Protein Science paper I mentioned recently, but in the end the reviewers *did* actually improve the paper I think. You can read about the efforts of Jason (L), Sarah, Ana, Hinnerk, Mario, Mattias and Nick - with able assistance from Daniel in Canberra and Ben Parker - when you discover that CHD4 is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex.
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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