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GATA1-DNA structure published
The long-awaited structure of the double ZF of GATA1 bound to DNA - a pseudopalindromic site - has come out [Pubmed or PDF via journal] in Protein Science, thanks to the work of Lorna (including some *very* funky multi-coloured gel shifts), Krystal and Nina - and of course the inimitable David Jacques and Mitchell. Their work puts a dampener on the idea that GATA-1 might mediate DNA looping by having one ZF bind to a local site and the other to a distant site - which is just as well, otherwise Ldb1 would be left feeling redundant.
…still they keep coming!
What can we say - the lab is clearly a fertile place...Born August 2 (very early in the morning) in Hong Kong. Congratulations to Eija and Niko.
Two babies in one day?!
I think I can safely say that this is the first time we have had two 'lab babies' delivered on the same day... Raina Wong (PhD 2005) is now the proud mother of baby Alana.
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!
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