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Mitchell hits the big time in Berkeley
Mitchell O'Connell, who completed his PhD with Joel in 2013 has had a taste of success in the US with a first-author paper in Nature on work that he spearheaded in his postdoctoral position with Prof Jennifer Doudna in the Dept of Molecular and Cell Biology at Berkeley Science Minister's Prize. The paper follows an idea that Mitch had to adapt the Crispr/Cas9 system - the recently described protein family that has hit headlines as a programmable DNA-binding protein system for genome engineering - for the addressable recognition of RNA.
Jacqui invited to speak at the triennial GATA meeting in 2015
In the latest of a recent glut of international speaking invitations (Gordon Conference in the US and the Prague Spring Meeting being the most recent), Jacqui has been invited to speak at the GATA meeting, which will be held next year on the island of Kos in Greece. Nice for some!
Marylène’s paper on designer RNA-binding proteins has been accepted in Angew. Chem.
Slightly too late to allow us to celebrate with her, but a good belated going-away present nonetheless. Steph and Mitch also put in plenty of work and several other people in the lab were involved too... The full citation is: Engineering Specificity Changes on a RanBP2 Zinc Finger that binds single-stranded RNA Marylène Vandevenne, Mitchell R. O'Connell, Stephanie Helder, Nicholas E. Shepherd, Jacqueline M. Matthews, Ann H. Kwan, David J. Segal, and Joel P. Mackay* (2014) Angew. Chem. in press. Yay!
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!
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