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Jason gets hitched
Recently, Jason tied the knot with Dr Melissa Erce in a ceremony in Pymble that was followed by a splendid and intricately organized reception at the Sergeant's Mess at Chowder Bay. Both events were attended by a number of lab members - but for those of you who weren't there, here is the happy couple! We hope they can settle down and start a nice collection of high-impact papers together...
Gracing the cover of JBC…
Dave Gell's latest paper, on which Mitchell and Joel made a small contribution, has been featured on the cover of JBC. The paper, which is built on fantastic work by Claire Dickson, Kaavya Krishna Kumar and David Jacques, shows the structure of a bacterial iron acquisition protein bound to mammalian hemoglobin. You can see very nicely from the structure how the heme is probably plucked out of the Hb by the bacterial protein. J Biol Chem (2014) ePub ahead of print. Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus. Dickson CF, Krishna Kumar K, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA....
Latest lab paper
A small invited commentary in J Mol Biol on non-specific DNA-binding proteins...
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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