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Lab retreat done and dusted for 2013
The annual lab retreat to Hyam's Beach (whitest sand in the world - and possibly the squeakiest too) went off without any significant hitches last weekend. Fantastic weather, and we even had some intrepid cyclists transporting themselves the 30 km from Nowra to Hyam's, most likely to work up a thirst. Michael has kindly gathered together the weekend's top quotes (which I have edited for taste): Masterchef has definitely been missing the pure genius of simply slopping some ice cream on some crumpets. For some reason there is something about rolling two little pigs like dice that makes me feel unethical. I can definitely look past the racist undertones of this game. There is so much fat...
Another boy off to Blighty
Morgan has fared us well now and headed off to the UK to work with Alessio Ciulli, who works on the structural biology of protein-protein interactions (sounds familiar!) and who is in the process of moving from Cambridge to Dundee. I hope Morgan has packed his winter sporren..
Flyp’s latest paper is out…
Congrats Flyp (and Chu Wai and Ann and others...!): Stokes et al., (2013) Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8 J Mol Biol 425, 1101-10.
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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