MACKAY & MATTHEWS LAB

Protein structure, function and engineering

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Varroa pesticide work hits the headlines

Unsurprisingly, there has been a significant surge in interest in Varroa mites in the last month or so, with the outbreak in NSW. This has resulted in quite a lot of publicity for our work on selective pesticides to tackle the mite, with the latest being an article on the ABC News website.  

Varroa research gets a mention in Japan!

Japan's Science and Technology Agency has picked up the recent publicity around our Varroa-mite-specific pesticide project by featuring it briefly on their website. Tash will be able to read it to you!

A NuRD for all seasons…

...is the title of our new review that is going to appear in Trends in Biochem Sci very soon. A sneak preview is here. In the paper - shaped by Xavier and Jason - we ponder on the observation that multiple paralogues are observed for all members of our favourite chromatin remodelling complex - the Nucleosome Remodelling and Deacetylase (NuRD) complex. This phenomenon has been observed for other remodelling complexes too (and likely many other types of protein complex). A couple of recent papers provide data that point to NuRD assemblies that are composed of a specific paralogue combination. This paper by Dan Bauer's group is the best example - they observe that repression of the fetal...

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!

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Update from Antonia

Update from Antonia

Antonia Zech - who worked with Ana for 5 months in 2013-4 as part of her Masters degree in Hamburg - has sent us an update on her activities. She has been doing a PhD at the Institute of Experimental Pharmacology and Toxicology at the University Medical Center...

New lab paper hits the streets

New lab paper hits the streets

Well, this paper took quite some time to come to fruition. Biswa from Melbourne worked hard to extract a structure from some less than friendly NMR data on a protein that was gifted to us by Wayne Patrick (formerly in Otago, now in Victoria University Wellington)....

Xavier gets to put the gown on

Xavier gets to put the gown on

Xavier Reid graduated today with his BSc with first class Honours - and you can see him here accompanied by his co-supervisor, Dr Jason Low. No one will mention that Jason isn't wearing his UNSW gown... Xavier has taken the plunge to come back and start a PhD -...

A nice piece of work from Nina

A nice piece of work from Nina

Nina Ripin, who spent some months in the lab as a Masters' student in 2011, is the lead author on a nice study focused on the RNA-binding properties of HuR in the latest PNAS. She has combined NMR and X-ray crystallography while working in Fred Allain's lab at ETH...

Lab Xmas bbq, 2018

Lab Xmas bbq, 2018

This year, we had a return to the green lawn of Marrickville Croquet Club for our lab Xmas excursion. As always, a fine time was had by all - it really is a great venue for a day...

What more could you ask for…

What more could you ask for…

...as a thank you PhD present? I can't decide which is my favourite part - the craft beer, the Clif bars that have been lovingly brought all the way from the US or the NMR needlepoint! Well, OK, I can decide... Thanks very much Taylor! And great to hear that the...