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Jacqui’s LIM complex structure used as eye candy!
The new Leeds Institute of Molecular Medicine (LIMM - nice...) has a vert attractive logo on their website! Can you pick which structure it is?
The 800 MHz spits out its first HSQC!
Woo-hooo - the new Bruker Avance 3 800-MHz NMR spectrometer recorded its first 15N and 13C HSQC spectra today, so we have taken our first steps in the ultra-high-field world. Exciting! The cryosystem and probe will be installed over the next 10 days or so, and then we will be rocking! Please submit purified and double/triple labelled proteins (and their binding partners, preferably!) at your leisure...
Mugdha and Ingrid blitz the Lorne Conference!
Mugdha and Ingrid both won poster prizes at the recent Lorne Conference on Protein Structure and Function for their presentations on LIM homeodomain and hydrophobin proteins, respectively. Miriam-Rose Ash and David Jacques from the crystallography side of the structural biology unit also picked up prizes too - not a bad haul overall!
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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