{"id":4766,"date":"2020-12-04T21:33:36","date_gmt":"2020-12-04T10:33:36","guid":{"rendered":"http:\/\/mackaymatthewslab.org\/wp\/?p=4766"},"modified":"2020-12-04T21:33:36","modified_gmt":"2020-12-04T10:33:36","slug":"a-truncated-tim-barrel","status":"publish","type":"post","link":"https:\/\/mackaymatthewslab.org\/wp\/blog\/2020\/12\/04\/a-truncated-tim-barrel\/","title":{"rendered":"A truncated TIM barrel"},"content":{"rendered":"<p>[\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore.do?structureId=2KZH\" target=\"_blank\" rel=\"noopener noreferrer\">PDB file<\/a>\u00a0] [\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science?_ob=ArticleListURL&amp;_method=list&amp;_ArticleListID=1659294887&amp;_sort=r&amp;_st=13&amp;view=c&amp;_acct=C000008818&amp;_version=1&amp;_urlVersion=0&amp;_userid=115085&amp;md5=13427201f1b2783f9d68206baf2b2dd1&amp;searchtype=a\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed link<\/a>\u00a0]<\/p>\n<p>The (\ufffda)8 barrel is one of the most common protein folds and it is thought it was one of the very first protein folds to emerge. Our collaborator\u00a0<a href=\"http:\/\/www.massey.ac.nz\/~imbs\/Staff\/patrick.htm\">Wayne Patrick<\/a>\u00a0previously isolated a three-quarter barrel that is soluble and almost as thermostable as full-length protein (PRAI). Our NMR structure of this three-quarter barrel shows that, despite missing a quarter of the normal foled, the subdomain is monomeric, well ordered and adopts a native-like structure in solution. These proteins &#8211; they&#8217;re crazy&#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[\u00a0PDB file\u00a0] [\u00a0PubMed link\u00a0] The (\ufffda)8 barrel is one of the most common protein folds and it is thought it was one of the very first protein folds to emerge. Our collaborator\u00a0Wayne Patrick\u00a0previously isolated a three-quarter barrel that is soluble and almost as thermostable as full-length protein (PRAI). Our NMR structure of this three-quarter barrel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4670,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[35],"tags":[],"class_list":["post-4766","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-structure-gallery"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2020\/12\/2KZH.png?fit=2000%2C2000&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4766","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/comments?post=4766"}],"version-history":[{"count":1,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4766\/revisions"}],"predecessor-version":[{"id":4775,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4766\/revisions\/4775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media\/4670"}],"wp:attachment":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media?parent=4766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/categories?post=4766"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/tags?post=4766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}