{"id":4802,"date":"2020-12-04T21:52:35","date_gmt":"2020-12-04T10:52:35","guid":{"rendered":"http:\/\/mackaymatthewslab.org\/wp\/?p=4802"},"modified":"2020-12-04T21:52:35","modified_gmt":"2020-12-04T10:52:35","slug":"a-c-terminal-domain-of-the-chromatin-remodeller-chd1","status":"publish","type":"post","link":"https:\/\/mackaymatthewslab.org\/wp\/blog\/2020\/12\/04\/a-c-terminal-domain-of-the-chromatin-remodeller-chd1\/","title":{"rendered":"A C-terminal domain of the chromatin remodeller CHD1"},"content":{"rendered":"<p>[\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=2n39\" target=\"_blank\" rel=\"noopener noreferrer\">PDB file<\/a>\u00a0] [\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27591891\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed link<\/a>\u00a0]<\/p>\n<p>Our collaborator (and former PhD student in Jacqui&#8217;s lab) Daniel Ryan identified a conserved region in CHD1 that hadn&#8217;t previously been appreciated. It turned out to be nicely structured and Biswa and Ana together were able to work it up to solve its structure by NMR. Steph helped out by looking to see whether it was a DNA-binding domain &#8211; seems to have some DNA-binding activity that is non-specific &#8211; which might well be functionally relevant.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[\u00a0PDB file\u00a0] [\u00a0PubMed link\u00a0] Our collaborator (and former PhD student in Jacqui&#8217;s lab) Daniel Ryan identified a conserved region in CHD1 that hadn&#8217;t previously been appreciated. It turned out to be nicely structured and Biswa and Ana together were able to work it up to solve its structure by NMR. Steph helped out by looking [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4680,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[35],"tags":[],"class_list":["post-4802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-structure-gallery"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2020\/12\/2n39.png?fit=1600%2C1600&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/comments?post=4802"}],"version-history":[{"count":2,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4802\/revisions"}],"predecessor-version":[{"id":4831,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/4802\/revisions\/4831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media\/4680"}],"wp:attachment":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media?parent=4802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/categories?post=4802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/tags?post=4802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}