{"id":7491,"date":"2022-06-15T18:56:38","date_gmt":"2022-06-15T08:56:38","guid":{"rendered":"https:\/\/mackaymatthewslab.org\/wp\/?p=7491"},"modified":"2022-06-15T18:56:47","modified_gmt":"2022-06-15T08:56:47","slug":"new-lab-preprint-on-the-mechanism-of-chd4-driven-chromatin-remodelling","status":"publish","type":"post","link":"https:\/\/mackaymatthewslab.org\/wp\/blog\/2022\/06\/15\/new-lab-preprint-on-the-mechanism-of-chd4-driven-chromatin-remodelling\/","title":{"rendered":"New lab preprint &#8211; on the mechanism of CHD4-driven chromatin remodelling"},"content":{"rendered":"<p>Our new preprint has taken forever but is now on <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.06.13.496015v1\">biorxiv<\/a> &#8211; WHEW! We (Jessica, Hakimeh, and Bishnu &#8211; with great support from Jason, Ana, Stefan, Chandrika &#8211; and Santosh at the Synchrotron) examine the auxiliary domains of chromatin remodeller CHD4, finding an IDR that promotes remodelling in a way that is dependent on its amino-acid composition but not the sequence, an autoinhibitory domain that binds the DNA translocase domain and a SANT-SLIDE that binds DNA and relieves autoinhibition.<\/p>\n<p>Now to see if a journal likes it! Wish us luck&#8230;<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2022\/06\/infographic.png?ssl=1\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-7489\" src=\"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2022\/06\/infographic.png?resize=1024%2C834&#038;ssl=1\" alt=\"\" width=\"1024\" height=\"834\" srcset=\"https:\/\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2022\/06\/infographic-980x798.png 980w, https:\/\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2022\/06\/infographic-480x391.png 480w\" sizes=\"auto, (min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/a><a id=\"set-post-thumbnail\" class=\"thickbox\" href=\"https:\/\/mackaymatthewslab.org\/wp\/wp-admin\/media-upload.php?post_id=7491&amp;type=image&amp;TB_iframe=1\">Set featured image<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our new preprint has taken forever but is now on biorxiv &#8211; WHEW! We (Jessica, Hakimeh, and Bishnu &#8211; with great support from Jason, Ana, Stefan, Chandrika &#8211; and Santosh at the Synchrotron) examine the auxiliary domains of chromatin remodeller CHD4, finding an IDR that promotes remodelling in a way that is dependent on its [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7492,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[26],"tags":[],"class_list":["post-7491","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2022\/06\/temp.png?fit=2000%2C1476&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/7491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/comments?post=7491"}],"version-history":[{"count":1,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/7491\/revisions"}],"predecessor-version":[{"id":7493,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/7491\/revisions\/7493"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media\/7492"}],"wp:attachment":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media?parent=7491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/categories?post=7491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/tags?post=7491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}