{"id":8573,"date":"2025-09-25T20:03:02","date_gmt":"2025-09-25T10:03:02","guid":{"rendered":"https:\/\/mackaymatthewslab.org\/wp\/?p=8573"},"modified":"2025-09-25T20:04:22","modified_gmt":"2025-09-25T10:04:22","slug":"karishma-and-biswas-magnum-opus-makes-it-onto-biorxiv","status":"publish","type":"post","link":"https:\/\/mackaymatthewslab.org\/wp\/blog\/2025\/09\/25\/karishma-and-biswas-magnum-opus-makes-it-onto-biorxiv\/","title":{"rendered":"Karishma (and Biswa&#8217;s) magnum opus makes it onto Biorxiv"},"content":{"rendered":"<p>The first step in the publication journey&#8230; This is the paper that describes our BET inhibitors that are super-selective &#8211; one of which seems to act by sensing differences in conformational dynamics between paralogues. It only binds to BRD2-BD1 &#8211; the only BD1 that shows *no* ms-us timescale dynamics. Very cool (we think)! We&#8217;ve sent it to a journal &#8211; let&#8217;s hope we don&#8217;t have to send it to 20!<\/p>\n<p>You can find it here, in all its glory:\u00a0 <a href=\"http:\/\/biorxiv.org\/content\/early\/2025\/09\/24\/2025.09.24.678353\">http:\/\/biorxiv.org\/content\/early\/2025\/09\/24\/2025.09.24.678353<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The first step in the publication journey&#8230; This is the paper that describes our BET inhibitors that are super-selective &#8211; one of which seems to act by sensing differences in conformational dynamics between paralogues. It only binds to BRD2-BD1 &#8211; the only BD1 that shows *no* ms-us timescale dynamics. Very cool (we think)! We&#8217;ve sent [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8574,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[26],"tags":[],"class_list":["post-8573","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/mackaymatthewslab.org\/wp\/wp-content\/uploads\/2025\/09\/fig3_patel.png?fit=726%2C650&ssl=1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/8573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/comments?post=8573"}],"version-history":[{"count":3,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/8573\/revisions"}],"predecessor-version":[{"id":8577,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/posts\/8573\/revisions\/8577"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media\/8574"}],"wp:attachment":[{"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/media?parent=8573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/categories?post=8573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mackaymatthewslab.org\/wp\/wp-json\/wp\/v2\/tags?post=8573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}