by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] In order to get an idea of the conformation of SS3 at a sub-zero temperature, we determined the structure of SS3 at -5 degrees Celcius. Getting the solution down to that temperature without freezing was straighforward – slow cooling...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Many animals that live in extremely cold climates produce proteins that act to prevent the formation of ice crystals in the bodily fluids of the organism. Antarctic fish produce a range of such proteins, as the water temperatures can drop...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] This structure shows a two-residue insertion mutant of BKLF F3 that possesses native function but not native structure. This zinc finger retains the ability to bind to GATA-1, even though it contains two additional bulky residues in a structurally...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] This protein is tryptophan-containing mutant of BKLF F3 that retains native structure and function. The addition of tryptophan enables the use of fluorescence spectroscopy for conducting folding studies.
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Red blood cells contain an excess of the alpha-chain of hemoglobin over the beta-chain. It is known that excess alpha-globin is unstable, and its precipitation can lead to membrane damage and apoptosis. This phenomenon is the root of the...