by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] FOG-1 is vital for the development of red blood cells and platelets. Originally identified as a Friend of GATA, GATA-independent functions are now emerging. Recently, we identified TACC3 as a protein partner of FOG-1. FOG-1 uses its third...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] The transcriptional regulator LMO4 consists entirely of two LIM domains, and must bind to the partner protein ldb1 in order to be transported into the nucleus and carry out its role in the regulation of lymphogenesis. We have determined...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] BKLF is a transcriptional repressor involved in erythropoiesis. It has been shown to interact with both DNA (CACCC boxes) and the C-terminal zinc finger of GATA-1. We have determined its solution structure as a first step towards...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Shown is the structure of a mutant of Mi2-P2, with the second flexible loop (called L3) replaced by the corresponding region from another PHD domain from the protein WSTF. This structure shows that the PHD fold is indeed preserved in the...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] We have used NMR methods to determine the solution structure of the second PHD finger from the transcriptional regulator Mi2b. This structure indicates that PHD fingers contain two relatively flexible loop regions (shown in orange and red)...