by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] This structure shows that the second NEAT domain of IsdH is involved in recognizing hemoglobin rather than extracting heme/iron. That task falls to the third NEAT domains (as elegantly shown from Claire Dickson’s structure in the...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] We have shown previously that a two-zinc finger unit found in the transcriptional coregulator ZNF217 recognizes DNA but with an affinity and specificity that is lower than other classical ZF arrays. To investigate the basis for these...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Hydrophobins spontaneously self-assemble into functional amyloid monolayers at hydrophobic:hydrophilic interfaces. These amphipathic monolayers have amazing physicochemical properties and have been suggested for many different...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] In developing neuronal tissue expression of the key specification factor Lhx3 is supplemented by the redundant protein Lhx4. In motor neurons the balance between Lhx3 and Isl1 is critical for proper cell fate determination. In order to...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Fungi make a hydrophobic coating on their spores by assembling an amphipathic surface monolayer made from small proteins termed hydrophobins. In an effort to try to understand the structural basis for the non-covalent assembly process (in...