by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for the normal regulation of gene expression in a wide range of organisms (even plants!). We are slowly trying to build up a picture of how NuRD works at a mechanistic...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for the normal regulation of gene expression in a wide range of organisms (even plants!). We are slowly trying to build up a picture of how NuRD works at a mechanistic...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] FOG1 is a coregulator protein that assists the transcription factor GATA1 in the control of gene expression during erythroid development. Gerd Blobel, a collaborator of ours in Philadelphia, showed that at least part of the mechanism by...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] The two zinc fingers of ZRANB2 (formerly known as ZNF265) can bind to single-stranded RNA with high sequence specificity. We have determined the structure of one of these fingers bound to its RNA target site (AGGUAA – determined by...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] MED-1 is a GATA-family transcription factor that is essential for development in Caenorhabditis elegans. It’s single GATA-type zinc finger was shown by Morris Maduro to bind to a long and slightly divergent DNA site (GTATACTTTT),...