by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Nina Ripin, a German Masters student, was able to determine this structure with help from David Jacques and Mitchell Guss. analysis of the structure indicates that although the N-terminal ZF (NF) can modulate GATA1 DNA binding, the NF...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Many years ago, Gerd and I spotted a section of FOG1 outside the ZFs that looked like it might have been ordered. After only 12 years or so, Joel finally finished solving the structure of the domain (which is only ~110 residues, so who...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] A *third* structure of the RbAp48-MTA1 subcomplex – just for good measure. No extra interactions this time though…
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] A second structure of the RbAp48-MTA1 subcomplex. A little bit more of MTA1 gave a substantially higher affinity, which can be rationalized in the structure by the formation of an additional hydrophobic cluster.
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] RbAP48 and MTA1 are components of the Nucleosome Remodeling and Deacetylase (NuRD) complex. This structure provides a small step towards understanding how the complex is put together. Still plenty more to be done though!