by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] BKLF is a transcriptional repressor involved in erythropoiesis. It has been shown to interact with both DNA (CACCC boxes) and the C-terminal zinc finger of GATA-1. We have determined its solution structure as a first step towards...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Shown is the structure of a mutant of Mi2-P2, with the second flexible loop (called L3) replaced by the corresponding region from another PHD domain from the protein WSTF. This structure shows that the PHD fold is indeed preserved in the...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] We have used NMR methods to determine the solution structure of the second PHD finger from the transcriptional regulator Mi2b. This structure indicates that PHD fingers contain two relatively flexible loop regions (shown in orange and red)...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Bacterial superantigens are involved in overstimulating T cells. YPM has a structure that is unique amongst classical superantigens. Typical superantigens consist of 2 b-strand domains and a central α-helix. However YPM consists of 8...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] We have solved the structure of a complex of the transcription regulators LMO4 and ldb1 (PDB: 1M3V). To do this we engineered FLIN4, a fusion of the LID domain of ldb1 and the N-terminal LIM domain of LMO4. The structure of FLIN4 shows...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] FLIN2 (PDB: 1J2O) is an engineered intramolecular complex comprising a fusion of the LID domain of ldb1 and the N-terminal LIM domain of LMO2. The solution structure of FLIN2 shows that ldb1-LID (yellow ribbon) binds to the LMO2 LIM1...