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Structure of the GATA-FOG complex published in PNAS
After about 7 years of painstaking work (!), we have finally been able to solve and publish the structure of the complex formed between the N-terminal zinc finger of GATA-1 and a classical finger from FOG. This work was made very difficult by the weak nature of the complex (~104-105 M-1), which presented line-broadening problems. Finally though, we got there and were able to report the structure in PNAS (Track II) - a great relief for all involved! Now to bring in other members of these complexes...
New research fellow to come to the lab
Dr Roland Gamsjaeger from the University of Linz was awarded an Austrian Shroedinger Fellowship to come to the lab for two years - Roland will arrive in a couple of months and brings expertise in Biacore and AFM with him.
Janet’s structure of the LMO2:ldb1 complex published in EMBO J.
The structure of the complex formed between full-length LMO4 and the LMO4-binding region of ldb1 was published recently in EMBO J. This structure revealed a very unusual binding mode - a tandem beta-zipper, in which the ldb1 forms additional beta-strands to add on to hairpins in both of the LIM domains. The structure provides an extremely extended interface, and Daniel and others have been able to map the important residues for binding using mutagenesis and yeast two-hybrid experiments. Now the design work can begin!
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
Amazing story from the lab down the corridor - @RezwanSidd working with Sandro Ataide and Ruth Hall in @SydneySOLES at @Sydney_Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! 🙂 Great piece of work!
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