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Philippa et al organize the East Coast Protein meeting
On 24-26 June this year, the SPG and QPG will be co-hosting the East Coast Protein meeting at the luxurious Opal Cove Resort in Coffs Harbour. This year, the meeting will be organized almost entirely by Philippa Stokes, Sharon Pursglove, Molly Clifton, Ann Kwan and Kate Edwards. So far, they have secured two invited speakers, and plenty of sponsorship money, ensuring that the conference will be a great success (as long as they can get a few registrants...). Looking good so far!
Mike wins poster prize at Lorne Protein Conference
Mike Swanton capped off his PhD in the lab by winning one of the poster prizes at the 2005 Lorne Protein Conference for a presentation on the work he has been carrying out over the last couple of years on zinc-finger:DNA interactions. This work has been going well over the last 10 months or so, and the meeting was a great chance for Mike to show people what he had achieved in this time.
Structure of the GATA-FOG complex published in PNAS
After about 7 years of painstaking work (!), we have finally been able to solve and publish the structure of the complex formed between the N-terminal zinc finger of GATA-1 and a classical finger from FOG. This work was made very difficult by the weak nature of the complex (~104-105 M-1), which presented line-broadening problems. Finally though, we got there and were able to report the structure in PNAS (Track II) - a great relief for all involved! Now to bring in other members of these complexes...
Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: https://usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_CAREER_SITE/job/Darlington-Campus/Postdoctoral-Researcher-in--Peptide-Based-Drug-Discovery_0131612-1
Email for more info: joel.mackay@sydney.edu.au
Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?
This is supercool, but it does like folding everything, even things that are probably disordered... As always, use with caution, and consult your friendly structural biologist before investing too much in low confidence predictions.
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