by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] In developing V2 interneurons (and various other tissues) the LIM domains of Lhx3 must contact the LIM-interaction domain of Ldb1 as part of a transcription complex that specifies the cell type. This is how they do it. The Lhx3 is in blue...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] We have used a variety of NMR, mutagenesis and binding data to build a model of the interaction between zinc finger 5 from the neuronal transcription factor MyT1 and its cognate DNA site. The model was built using the HADDOCK data-driven...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] MyT1 is a zinc finger transcription factor that is involved in neuronal development, controlling genes that are important for myelin sheath formation. It contains 7 zinc fingers with an unusual consensus sequence, and these domains have...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] The THAP (Thanatos-associated protein) domain is a recently discovered zinc-binding domain found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. It contains a single zinc atom...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Homeodomain-only protein (HOP) is an 8-kDa transcriptional corepressor that is essential for the normal development of the mammalian heart. A combination of sequence comparison and our structural data revealed that HOP consists entirely of...