by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] p22HBP is a 22-kDa mammalian protein that is highly upregulated during erythroid development, and appears to be a target gene of GATA-1. Its function is currently unknown, although it has been reported to bind to a range of different...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] Hydrophobins are small fungal proteins that form polymeric fibrils, known as rodlets. These rodlets form a matted coating on the surface of aerial structures like air-dispersed spores. The coating is extremely amphipathic, with an outward...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] This CHANCE peptide was one of two (+DFF5) designed to mimic the GATA-binding surface of the transcriptional repressor U-shaped. NMR structural work showed both that DFF7 was well-folded (right) and that the grafted residues occupied...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] This CHANCE peptide was designed to mimic the GATA-binding surface of the transcriptional repressor U-shaped. We have previously defined the surface involved in this interaction, and we attempted to transplant this surface onto the minimal...
by Joel Mackay | Dec 4, 2020 | Structure Gallery |
[ PDB file ] [ PubMed link ] This is one of the first CHANCE peptides that was designed to emulate the binding function of another protein. The N-terminal nucleocapsid domain (NUC1, left) of the HIV-1 nucleocapsid protein is able to bind to a short oligonucleotide...